The number of children in low-income countries that do not develop according to their potential is large. Our results indicate that correcting children`s vitamin B12 status early may be one measure to secure a healthy development for these vulnerable children. We are currently in the process of confirming our results in randomized controlled trials, says Kvestad
Kvestad’s colleauge Mari Hysing at Uni Research is among the study co-authors.
The other study contributors have their affiliation at Innlandet Hospital Trust, the Tribhuvan University Teaching Hospital in Nepal, Center for Intervention Studies in Maternal and Child Health (CISMAC) at the University of Bergen, Oslo and Akershus University College, Haukeland University Hospital, Harvard T.H. Chan School of Public Health and Johns Hopkins Bloomberg School of Public Health. In low income countries, and in particular in South Asia where many eat limited amounts of meat and other animal products, poor vitamin B12 status is prevalent. Previous findings indicate that vitamin B12 is important for the developing brain. The researchers collected blood from 500 infants in Bhaktapur, Nepal, and measured their B12 status. Approximately 5 years later they contacted 320 of these children and conducted various developmental and cognitive tests.
One of the 320 study participants. A five year old child in Nepal, solving cognitive tests. (Photograph: Uni Research)
Most of the Nepalese children participating in the study did not have severely low levels of vitamin B12, but their levels were suboptimal, below the recommendations for best possible growth and development, says Kvestad. It’s like a hidden deficiency of the vitamin in these children’s bodies, making their cells work rigorously to signalize imminent danger. Our study is one contribution in the big puzzle to understand the implications low B12 levels might have on small children’s cognitive development, says Kvestad.