When mice were injected with the parasite, Professor Cermakian’s team discovered that their immune response varied greatly depending on what time of day the infection occurred. “Our previous work showed that our immune system has its own biological clocks. Our body’s defence mechanisms are more or less active at different times of the day,” says Nicolas Cermakian, lead author of the new study published in Scientific Reports in collaboration with McGill/RI-MUHC Professor Martin Olivier and Professor Nathalie Labrecque of Université de Montréal and Maisonneuve-Rosemont Hospital research centre.
Silke Kiessling, a former postdoctoral student in Professor Cermakian’s lab, found that Leishmania’s infection was more effective in the early night, a time when the immune response to the parasite was the strongest. But why would the parasite be transmitted by a fly that bites at the exact time when our defences are at their strongest? Simply put, the parasite thrives when it elicits a strong immune response, attracting inflammatory cells it uses to multiply (macrophages and neutrophils) to the infection site. “We already knew that viral and bacterial infections were controlled by our immune system’s circadian rhythms, but this is the first time this is shown for a parasitic infection, and for a vector-transmitted infection,” Professor Cermakian adds.
Tools for better treatment and prevention
Professor Cermakian’s team will now try to better define how Leishmania’s circadian rhythm is controlled at the molecular and cellular levels. As a first step, they already found that the clock within cells of the immune system is directing the daily rhythm of response to Leishmania. A better understanding of how the circadian clock controls Leishmania infection could contribute to the development of new therapeutics and better prevention approaches. Working out how time regulation of host-parasite interactions are controlled, Cermakian says, might also be useful in the fight against other diseases transmitted by insects.