Scienceonline - Last News

Single brain scan can diagnose Alzheimer’s disease

Single brain scan can diagnose Alzheimer’s disease

23 Giugno 2022

A single MRI scan of the brain could be enough...

Researchers create ‘time machine’ simulations studying the lifecycle of ancestor galaxy cities

Researchers create ‘time machine’ simulations studying the lifecycle of ancestor galaxy cities

06 Giugno 2022

For the first time, researchers have created simulations that directly...

Unlocking the secrets of killer whale diets and their role in climate change

Unlocking the secrets of killer whale diets and their role in climate change

20 Maggio 2022

Killer whale populations are invading the Arctic, causing significant disruptions...

New mechanism for regulating supply of DNA building blocks may lead to better antibiotics

New mechanism for regulating supply of DNA building blocks may lead to better antibiotics

19 Maggio 2022

In a new study published in Nature Communications, researchers from...

New study reveals impact of sea level rise on human groups during Mesolithic and Neolithic periods

New study reveals impact of sea level rise on human groups during Mesolithic and Neolithic periods

19 Maggio 2022

A study carried out in the area around the Pego-Oliva...

Snake-like limb loss in a Carboniferous amniote

11 Aprile 2022

Among living tetrapods, many lineages have converged on a snake-like...

Protein boosts height growth in girls

Protein boosts height growth in girls

07 Aprile 2022

Protein boosts height growth in girls. Just seven grams over...

Fungicide combo against devastating red clover disease

Fungicide combo against devastating red clover disease

07 Marzo 2022

Red clover, an important forage crop for grazing cattle, can...

Antibody responses after first and second Covid-19 vaccination in patients with chronic lymphocytic leukaemia

H Parry , G McIlroy , R Bruton 27 Dic 2021
744 volte

 

B-cell chronic lymphocytic leukaemia (CLL) is associated with immunosuppression and patients are at increased clinical risk following SARS-CoV-2 infection. Covid-19 vaccines offer the potential for protection against severe infection but relatively little is known regarding the profile of the antibody response following first or second vaccination. We studied spike-specific antibody responses following first and/or second Covid-19 vaccination in 299 patients with CLL compared with healthy donors. 286 patients underwent extended interval (10-12 week) vaccination. 154 patients received the BNT162b2 mRNA vaccine and 145 patients received ChAdOx1.

Blood samples were taken either by venepuncture or as dried blood spots on filter paper. Spike-specific antibody responses were detectable in 34% of patients with CLL after one vaccine (n = 267) compared to 94% in healthy donors with antibody titres 104-fold lower in the patient group. Antibody responses increased to 75% after second vaccine (n = 55), compared to 100% in healthy donors, although titres remained lower. Multivariate analysis showed that current treatment with BTK inhibitors or IgA deficiency were independently associated with failure to generate an antibody response after the second vaccine. This work supports the need for optimisation of vaccination strategy in patients with CLL including the potential utility of booster vaccines.

Full article

Vota questo articolo
(0 Voti)

Lascia un commento

Assicurati di aver digitato tutte le informazioni richieste, evidenziate da un asterisco (*). Non è consentito codice HTML.

 

Scienzaonline con sottotitolo Sciencenew  - Periodico
Autorizzazioni del Tribunale di Roma – diffusioni:
telematica quotidiana 229/2006 del 08/06/2006
mensile per mezzo stampa 293/2003 del 07/07/2003
Scienceonline, Autorizzazione del Tribunale di Roma 228/2006 del 29/05/06
Pubblicato a Roma – Via A. De Viti de Marco, 50 – Direttore Responsabile Guido Donati

Photo Gallery