Intravenous Vitamin C whith Covid-19

Guido Donati 30 Ott 2023

In the study titled "Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials," conducted by Dr. Frank L. van de Veerdonk et al., and published in JAMA on October 25, 2023 (doi: 10.1001/jama.2023.21407), the potential implications of vitamin C use in hospitalized patients with COVID-19 were examined. The study involved two harmonized clinical trials, which enrolled critically ill patients in intensive care units at 90 different sites and non-critically ill patients at 40 sites across four continents.
Participants were randomly assigned to two groups: one group received intravenous vitamin C every 6 hours at a dose of 50 mg/kg of body weight for a total of 96 hours (up to 16 doses). The second group received a placebo or no vitamin C.

The primary outcome of the study was a composite measure of "organ support-free days," representing the number of days patients remained alive and without the need for respiratory or cardiovascular organ support in the intensive care unit up to day 21, along with survival to hospital discharge. The study revealed that vitamin C administered according to the described protocol had a very low probability of improving the primary outcome in both the critically ill and non-critically ill patient groups. Specifically, among critically ill patients, no significant improvements in organ support-free days were observed between the vitamin C group and the control group. Among non-critically ill patients, vitamin C did not significantly affect the primary outcome or hospital survival. In conclusion, this study suggests that administering vitamin C at a dose of 50 mg/kg of body weight via intravenous infusion every 6 hours for 96 hours does not appear to have a significant impact on improving the recovery and survival of hospitalized patients with COVID-19, regardless of whether they were critically ill or not. The full article is available at: Intravenous Vitamin C for Patients Hospitalized With COVID-19.

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Scienzaonline con sottotitolo Sciencenew  - Periodico
Autorizzazioni del Tribunale di Roma – diffusioni:
telematica quotidiana 229/2006 del 08/06/2006
mensile per mezzo stampa 293/2003 del 07/07/2003
Scienceonline, Autorizzazione del Tribunale di Roma 228/2006 del 29/05/06
Pubblicato a Roma – Via A. De Viti de Marco, 50 – Direttore Responsabile Guido Donati

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